Growth factor receptor-bound protein 2

URI: https://gptkb.org/entity/Growth_factor_receptor-bound_protein_2
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:GRB2
gptkbp:alternativeName gptkb:Grb2
gptkb:Growth_factor_receptor-bound_protein_2_homolog
gptkb:ASH
gptkbp:discoveredBy gptkb:Tony_Pawson
gptkbp:discoveredIn 1992
gptkbp:domain SH2 domain
SH3 domain
gptkbp:encodedBy gptkb:GRB2_gene
gptkbp:Entrez_Gene_ID 2885
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function adaptor protein in signal transduction
https://www.w3.org/2000/01/rdf-schema#label Growth factor receptor-bound protein 2
gptkbp:interactsWith gptkb:EGFR
gptkb:SOS1
gptkb:Shc
gptkbp:involvedIn cell differentiation
cell proliferation
oncogenic transformation
gptkbp:locatedOnChromosome gptkb:17q25
gptkbp:molecularWeight 25 kDa
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1GRI
gptkbp:requires embryonic development
gptkbp:roleInPathway gptkb:EGFR_signaling_pathway
gptkb:RAS/MAPK_signaling_pathway
gptkbp:subcellularLocation gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:UniProtID gptkb:P62993
gptkbp:bfsParent gptkb:GRB2
gptkbp:bfsLayer 6