Growth factor receptor-bound protein 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:GRB2
gptkbp:alternativeName	gptkb:Grb2 gptkb:Growth_factor_receptor-bound_protein_2_homolog gptkb:ASH
gptkbp:discoveredBy	gptkb:Tony_Pawson
gptkbp:discoveredIn	1992
gptkbp:domain	SH2 domain SH3 domain
gptkbp:encodedBy	gptkb:GRB2_gene
gptkbp:Entrez_Gene_ID	2885
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	adaptor protein in signal transduction
gptkbp:interactsWith	gptkb:EGFR gptkb:SOS1 gptkb:Shc
gptkbp:involvedIn	cell differentiation cell proliferation oncogenic transformation
gptkbp:locatedOnChromosome	gptkb:17q25
gptkbp:molecularWeight	25 kDa
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	gptkb:1GRI
gptkbp:requires	embryonic development
gptkbp:roleInPathway	gptkb:EGFR_signaling_pathway gptkb:RAS/MAPK_signaling_pathway
gptkbp:subcellularLocation	gptkb:cytoplasm gptkb:plasma_membrane
gptkbp:UniProtID	gptkb:P62993
gptkbp:bfsParent	gptkb:GRB2
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	Growth factor receptor-bound protein 2