|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
phosphorylated tyrosine residues
|
|
gptkbp:discoveredBy
|
gptkb:Tony_Pawson
|
|
gptkbp:domain
|
SH2 domain
SH3 domain
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000177885
2885
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Growth_factor_receptor-bound_protein_2
|
|
gptkbp:function
|
adaptor protein in signal transduction
|
|
gptkbp:gene
|
gptkb:GRB2
|
|
gptkbp:HGNC_ID
|
4566
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Grb2
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:FGFR
gptkb:c-Met
gptkb:SOS1
gptkb:Shc
|
|
gptkbp:involvedIn
|
gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
|
|
gptkbp:length
|
217 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q25
|
|
gptkbp:molecularWeight
|
~25 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:OMIM
|
108355
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1GRI
|
|
gptkbp:phosphorylates
|
gptkb:tyrosine
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell migration
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:PDB
gptkb:UniProt
gptkb:Ensembl
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P62993
|
|
gptkbp:bfsParent
|
gptkb:c-Met
gptkb:SH3KBP1
gptkb:IRS1
|
|
gptkbp:bfsLayer
|
6
|