|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:hepatocyte_growth_factor_receptor
|
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gptkbp:associatedWith
|
gptkb:cancer
gastric cancer
renal cell carcinoma
|
|
gptkbp:discoveredBy
|
gptkb:George_F._Vande_Woude
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:domain
|
tyrosine kinase domain
PSI domain
Sema domain
|
|
gptkbp:downstreamOf
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gptkb:MAPK_pathway
gptkb:STAT_pathway
gptkb:Ras_pathway
gptkb:PI3K-Akt_pathway
|
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gptkbp:encodedBy
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gptkb:MET_gene
|
|
gptkbp:formsComplexWith
|
gptkb:PLCĪ³
gptkb:Src
gptkb:PI3K
gptkb:Gab1
gptkb:Grb2
gptkb:STAT3
|
|
gptkbp:function
|
morphogenesis
cell growth
cell motility
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
c-Met
|
|
gptkbp:involvedIn
|
wound healing
angiogenesis
epithelial-mesenchymal transition
|
|
gptkbp:ligand
|
hepatocyte growth factor
|
|
gptkbp:locatedOnChromosome
|
7q31
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
oncogenic activation
|
|
gptkbp:orthologIn
|
gptkb:mouse_Met_protein
|
|
gptkbp:phosphorylates
|
Y1234
Y1235
Y1349
Y1356
|
|
gptkbp:regulates
|
endocytosis
ubiquitination
proteolytic cleavage
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
single-pass transmembrane protein
|
|
gptkbp:target
|
gptkb:crizotinib
gptkb:capmatinib
gptkb:savolitinib
gptkb:tepotinib
|
|
gptkbp:UniProtID
|
P08581
|
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gptkbp:bfsParent
|
gptkb:receptor_tyrosine_kinases
|
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gptkbp:bfsLayer
|
5
|