|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:SOD2
gptkb:Mitochondrial_superoxide_dismutase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
amyotrophic lateral sclerosis
|
|
gptkbp:cofactor
|
manganese
|
|
gptkbp:discoveredBy
|
gptkb:Irwin_Fridovich
|
|
gptkbp:discoveredIn
|
1969
|
|
gptkbp:EC_number
|
1.15.1.1
|
|
gptkbp:Entrez_Gene_ID
|
6648
|
|
gptkbp:expressionRegulation
|
upregulated by oxidative stress
|
|
gptkbp:fullName
|
gptkb:Manganese_superoxide_dismutase
|
|
gptkbp:function
|
catalyzes the dismutation of superoxide radicals to oxygen and hydrogen peroxide
|
|
gptkbp:gene
|
gptkb:SOD2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MnSOD
|
|
gptkbp:importantFor
|
protects cells from oxidative stress
|
|
gptkbp:inhibitedBy
|
inhibited by hydrogen peroxide
|
|
gptkbp:locatedOnChromosome
|
human chromosome 6q25.3
|
|
gptkbp:location
|
mitochondria
|
|
gptkbp:molecularWeight
|
about 96 kDa (human tetramer)
|
|
gptkbp:mutationAssociatedWith
|
mutations can cause mitochondrial dysfunction
|
|
gptkbp:organism
|
found in nearly all aerobic organisms
|
|
gptkbp:PDB
|
gptkb:1LUV
|
|
gptkbp:structure
|
homotetramer in humans
|
|
gptkbp:UniProtID
|
P04179
|
|
gptkbp:bfsParent
|
gptkb:FOXO
gptkb:SOD2
gptkb:Sod2
gptkb:superoxide_dismutase_2
|
|
gptkbp:bfsLayer
|
7
|