|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
dimerization
ligand binding
|
|
gptkbp:alternativeName
|
gptkb:ERBB2
gptkb:CD340
neu
|
|
gptkbp:clinicalTrialPhase
|
gptkb:FISH_(fluorescence_in_situ_hybridization)
immunohistochemistry
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodedBy
|
gptkb:ERBB2_gene
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:extracellularDomain
|
present
|
|
gptkbp:formsHeterodimerWith
|
gptkb:EGFR
gptkb:HER3
gptkb:HER4
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
cell growth regulation
|
|
gptkbp:HGNC_ID
|
3430
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HER2 receptor
|
|
gptkbp:intracellularDomain
|
present
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
gptkb:17q12
|
|
gptkbp:memberOf
|
gptkb:EGFR_family
|
|
gptkbp:molecularWeight
|
185 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
|
|
gptkbp:OMIM
|
164870
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
gastric cancer
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:structure
|
transmembrane glycoprotein
|
|
gptkbp:target
|
gptkb:ado-trastuzumab_emtansine
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:lapatinib
|
|
gptkbp:targetOfDrug
|
yes
|
|
gptkbp:transmembraneDomains
|
present
|
|
gptkbp:UniProtID
|
gptkb:P04626
|
|
gptkbp:bfsParent
|
gptkb:Herceptin
|
|
gptkbp:bfsLayer
|
6
|