Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cellular component
|
| gptkbp:composedOf |
gptkb:integrins
actin filaments adaptor proteins signaling proteins |
| gptkbp:connects |
cytoskeleton
extracellular matrix |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:cardiovascular_disease muscular dystrophy fibrosis |
| gptkbp:firstDescribed |
1970s
Benjamin Geiger |
| gptkbp:foundIn |
animal cells
|
| gptkbp:function |
signal transduction
cell adhesion mechanotransduction |
| gptkbp:GOID |
gptkb:GO:0005925
|
| gptkbp:hasProtein |
gptkb:Src_family_kinases
gptkb:paxillin gptkb:talin gptkb:vinculin focal adhesion kinase tensin zyxin α-actinin |
| https://www.w3.org/2000/01/rdf-schema#label |
Focal adhesion
|
| gptkbp:involvedIn |
cell differentiation
cell proliferation wound healing cell migration cell signaling cancer metastasis |
| gptkbp:locatedIn |
gptkb:plasma_membrane
|
| gptkbp:medium |
inside-out signaling
outside-in signaling |
| gptkbp:regulates |
cell survival
gene expression cell shape cell motility |
| gptkbp:relatedTo |
gptkb:cell_junction
adherens junction hemidesmosome |
| gptkbp:studiedIn |
cancer cells
endothelial cells fibroblasts epithelial cells |
| gptkbp:visualizes |
electron microscopy
immunofluorescence microscopy |
| gptkbp:bfsParent |
gptkb:ERBB2
gptkb:MMP2 gptkb:TIMP1 gptkb:COL1A2 |
| gptkbp:bfsLayer |
7
|