|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:c-ABL
JTK7
p150
v-ABL
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:chronic_myeloid_leukemia
leukemia
|
|
gptkbp:biologicalProcess
|
cell differentiation
signal transduction
cell division
cell adhesion
stress response
tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:David_Baltimore
|
|
gptkbp:encodes
|
gptkb:ABL_proto-oncogene_1,_non-receptor_tyrosine_kinase
|
|
gptkbp:Entrez_Gene_ID
|
25
ENSG00000097007
|
|
gptkbp:HGNC_ID
|
HGNC:76
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABL1
|
|
gptkbp:involves
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
BCR-ABL signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
fusion gene (BCR-ABL)
|
|
gptkbp:OMIM
|
189980
|
|
gptkbp:orthologInMouse
|
Abl1
|
|
gptkbp:PDB
|
gptkb:2J6M
1OPK
2FO0
2GQG
2HYY
2HZ4
2HZ8
2HZI
2HZN
2HZO
2HZS
2HZW
2HZY
2HZZ
2J6N
2J6O
2J6P
2J6Q
2J6R
2J6S
2J6T
2J6U
2J6V
2J6W
2J6X
2J6Y
2J6Z
2J70
2J71
2J72
2J73
2J74
2J75
2J76
2J77
2J78
2J79
2J7A
2J7B
2J7C
2J7D
2J7E
2J7F
2J7G
2J7H
2J7I
2J7J
2J7K
2J7L
2J7M
2J7N
2J7O
2J7P
2J7Q
2J7R
2J7S
2J7T
2J7U
2J7V
2J7W
2J7X
2J7Y
2J7Z
|
|
gptkbp:phosphorylates
|
gptkb:p73
gptkb:RAD51
gptkb:STAT5
CRKL
|
|
gptkbp:targetOfDrug
|
gptkb:bosutinib
gptkb:dasatinib
gptkb:ponatinib
gptkb:imatinib
gptkb:nilotinib
|
|
gptkbp:tissue_specificity
|
gptkb:cancer
gptkb:testis
brain
liver
spleen
hematopoietic cells
|
|
gptkbp:UniProtID
|
P00519
|
|
gptkbp:bfsParent
|
gptkb:ChEMBL651
gptkb:ERBB2
gptkb:Philadelphia_chromosome
gptkb:BCR
gptkb:CAIL2
|
|
gptkbp:bfsLayer
|
7
|