|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alsoKnownAs
|
gptkb:ErbB_family
|
|
gptkbp:dimerization
|
heterodimerization
homodimerization
|
|
gptkbp:discoveredBy
|
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:encodedBy
|
ERBB genes
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
cell signaling
regulation of cell differentiation
regulation of cell survival
regulation of cell growth
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EGFR family
|
|
gptkbp:ligand
|
gptkb:epidermal_growth_factor
heregulin
|
|
gptkbp:member
|
gptkb:EGFR
gptkb:HER3
gptkb:HER4
HER2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:glioblastoma
|
|
gptkbp:recipient
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:relatedTo
|
gptkb:cancer
targeted therapy
|
|
gptkbp:target
|
monoclonal antibodies
tyrosine kinase inhibitors
|
|
gptkbp:bfsParent
|
gptkb:ERBB3
gptkb:HER2/neu
gptkb:ERBB2
gptkb:HER2_receptor
gptkb:ErbB_family
gptkb:Her2
|
|
gptkbp:bfsLayer
|
7
|