Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
ligand binding
|
| gptkbp:alsoKnownAs |
gptkb:ErbB_family
|
| gptkbp:dimerization |
heterodimerization
homodimerization |
| gptkbp:discoveredBy |
gptkb:Stanley_Cohen
|
| gptkbp:discoveredIn |
1970s
|
| gptkbp:downstreamOf |
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway gptkb:JAK/STAT_pathway |
| gptkbp:encodedBy |
ERBB genes
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
cell signaling
regulation of cell differentiation regulation of cell survival regulation of cell growth |
| gptkbp:ligand |
gptkb:epidermal_growth_factor
heregulin |
| gptkbp:member |
gptkb:EGFR
gptkb:HER3 gptkb:HER4 HER2 |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
gptkb:glioblastoma |
| gptkbp:recipient |
gptkb:receptor_tyrosine_kinase
|
| gptkbp:relatedTo |
gptkb:cancer
gptkb:targeted_therapy |
| gptkbp:target |
monoclonal antibodies
tyrosine kinase inhibitors |
| gptkbp:bfsParent |
gptkb:ERBB3
gptkb:HER2_receptor |
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
EGFR family
|