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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:ERBB
gptkb:ERBB1
gptkb:HER1
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gptkbp:associatedWith
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gptkb:Head_and_neck_cancer
gptkb:Glioblastoma
gptkb:Colorectal_cancer
gptkb:Non-small_cell_lung_cancer
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gptkbp:biologicalProcess
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cell differentiation
cell proliferation
signal transduction
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gptkbp:cellularComponent
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gptkb:endosome
gptkb:nucleus
gptkb:plasma_membrane
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gptkbp:domain
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gptkb:Protein_kinase_domain
Furin-like cysteine-rich domain
L domain
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000146648
1956
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gptkbp:enzymeClassification
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gptkb:EC_2.7.10.1
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gptkbp:fullName
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gptkb:Epidermal_growth_factor_receptor
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gptkbp:function
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Receptor tyrosine kinase involved in the regulation of cell growth, survival, proliferation, and differentiation
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gptkbp:gene
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gptkb:EGFR
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gptkbp:goMolecularFunction
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protein tyrosine kinase activity
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https://www.w3.org/2000/01/rdf-schema#label
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EGFR HUMAN
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gptkbp:interactsWith
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gptkb:CBL
gptkb:ERBB3
gptkb:PIK3R1
gptkb:SHC1
gptkb:SRC
gptkb:ERBB2
gptkb:GRB2
gptkb:STAT3
gptkb:ERBB4
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gptkbp:length
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1210 amino acids
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gptkbp:ligand
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Amphiregulin
Betacellulin
Epidermal growth factor (EGF)
Epiregulin
Heparin-binding EGF-like growth factor (HB-EGF)
Transforming growth factor alpha (TGF-α)
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gptkbp:locatedOnChromosome
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gptkb:7p11.2
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gptkbp:location
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gptkb:Endosome
gptkb:Nucleus
gptkb:Cell_membrane
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gptkbp:molecularWeight
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134 kDa
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:PDB
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1M17
2GS6
2ITX
3POZ
4KRL
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gptkbp:phosphorylates
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Y1045
Y1068
Y1148
Y1173
Y992
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gptkbp:postTranslationalModification
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Phosphorylation
Ubiquitination
Glycosylation
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gptkbp:RefSeq
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NP_005219.2
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gptkbp:reviewedBy
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gptkb:UniProtKB/Swiss-Prot
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gptkbp:structure
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Single-pass type I membrane protein
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gptkbp:UniProtID
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gptkb:P00533
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gptkbp:bfsParent
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gptkb:P42336
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gptkbp:bfsLayer
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6
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