|
gptkbp:instanceOf
|
gptkb:cancer
brain tumor
glioma
|
|
gptkbp:abbreviation
|
GBM
|
|
gptkbp:affects
|
adults
rarely children
|
|
gptkbp:alsoKnownAs
|
gptkb:glioblastoma_multiforme
|
|
gptkbp:diagnosedBy
|
gptkb:CT_scan
MRI
biopsy
|
|
gptkbp:firstDescribed
|
1860
|
|
gptkbp:frequency
|
most common malignant brain tumor in adults
|
|
gptkbp:grades
|
gptkb:WHO_grade_IV
|
|
gptkbp:histology
|
microvascular proliferation
necrosis
pseudopalisading cells
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Glioblastoma
|
|
gptkbp:ICD-10_code
|
C71
|
|
gptkbp:ICD-O_code
|
9440/3
|
|
gptkbp:incidence
|
3 per 100,000 per year
|
|
gptkbp:location
|
brain
central nervous system
|
|
gptkbp:median_survival
|
12-15 months
|
|
gptkbp:mutationAssociatedWith
|
gptkb:TP53_mutation
gptkb:IDH-wildtype
EGFR amplification
MGMT promoter methylation
|
|
gptkbp:notableCase
|
gptkb:Beau_Biden
gptkb:John_McCain
gptkb:Ted_Kennedy
|
|
gptkbp:originatedIn
|
astrocytes
|
|
gptkbp:prognosis
|
poor
|
|
gptkbp:recurrence
|
common
|
|
gptkbp:riskFactor
|
radiation therapy
genetic predisposition
|
|
gptkbp:specialty
|
neurology
oncology
neurosurgery
|
|
gptkbp:symptom
|
nausea
vomiting
headache
cognitive impairment
seizures
personality changes
focal neurological deficits
|
|
gptkbp:treatment
|
gptkb:bevacizumab
gptkb:temozolomide
surgery
radiation therapy
chemotherapy
|
|
gptkbp:bfsParent
|
gptkb:chromosome_10
|
|
gptkbp:bfsLayer
|
6
|