Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activeSiteResidue |
ATP binding site
substrate binding site |
| gptkbp:conservedIn |
glycine-rich loop
APE motif DFG motif HRD motif |
| gptkbp:EC_number |
2.7.11.1
|
| gptkbp:firstDescribed |
1970s
|
| gptkbp:foundIn |
gptkb:protein
|
| gptkbp:function |
catalyzes phosphorylation of proteins
|
| https://www.w3.org/2000/01/rdf-schema#label |
Protein kinase domain
|
| gptkbp:inhibitedBy |
kinase inhibitors
|
| gptkbp:InterPro |
gptkb:IPR000719
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
genetic diseases |
| gptkbp:presentIn |
eukaryotes
serine/threonine kinases tyrosine kinases some prokaryotes dual-specificity kinases |
| gptkbp:proteinFamily |
gptkb:PF00069
PS50011 |
| gptkbp:requires |
apoptosis
cell cycle regulation metabolism cell signaling |
| gptkbp:structure |
bilobal fold
|
| gptkbp:bfsParent |
gptkb:PF00069
gptkb:EGFR_HUMAN gptkb:P21802 |
| gptkbp:bfsLayer |
7
|