|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:cofactor
|
gptkb:cytochrome_P450_reductase
NADPH
|
|
gptkbp:contains
|
gptkb:heme_cofactor
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Klingenberg
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
fungi
plants
|
|
gptkbp:fullName
|
gptkb:Cytochrome_P450
|
|
gptkbp:function
|
catalyzes oxidation of organic substances
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP450
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
gptkb:St._John's_Wort
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:macrolide_antibiotics
azole antifungals
|
|
gptkbp:involvedIn
|
cholesterol metabolism
detoxification
steroid synthesis
drug metabolism
|
|
gptkbp:location
|
gptkb:endoplasmic_reticulum
mitochondria
|
|
gptkbp:namedFor
|
absorption peak at 450 nm
|
|
gptkbp:proteinFamily
|
CYP
|
|
gptkbp:substrate
|
gptkb:methadone
gptkb:diclofenac
gptkb:ibuprofen
gptkb:arachidonic_acid
gptkb:progesterone
gptkb:paracetamol
gptkb:codeine
gptkb:cyclosporine
gptkb:theophylline
gptkb:warfarin
gptkb:aldosterone
gptkb:omeprazole
gptkb:chlorpromazine
gptkb:lidocaine
gptkb:clopidogrel
gptkb:tamoxifen
gptkb:estradiol
gptkb:erythromycin
gptkb:verapamil
gptkb:midazolam
gptkb:amitriptyline
gptkb:imipramine
gptkb:diazepam
gptkb:losartan
caffeine
propranolol
quinidine
statins
cholesterol
cortisol
vitamin D
acetaminophen
nicotine
fatty acids
retinoic acid
environmental toxins
xenobiotics
testosterone
bile acids
|
|
gptkbp:superfamilyMembers
|
gptkb:CYP1
gptkb:CYP11
gptkb:CYP17
gptkb:CYP19
gptkb:CYP2
gptkb:CYP21
gptkb:CYP24
gptkb:CYP27
gptkb:CYP3
gptkb:CYP4
gptkb:CYP46
gptkb:CYP51
gptkb:CYP7
gptkb:CYP8
CYP5
|
|
gptkbp:bfsParent
|
gptkb:D00203
|
|
gptkbp:bfsLayer
|
7
|