|
gptkbp:instanceOf
|
gptkb:antibiotic
class of organic compounds
|
|
gptkbp:ATCCode
|
J01FA
|
|
gptkbp:contraindication
|
known hypersensitivity
|
|
gptkbp:discoveredBy
|
gptkb:J._M._McGuire
1952
|
|
gptkbp:drugInteraction
|
CYP3A4 inhibitors
|
|
gptkbp:example
|
gptkb:azithromycin
gptkb:clarithromycin
gptkb:erythromycin
gptkb:roxithromycin
gptkb:telithromycin
spiramycin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
macrolide antibiotics
|
|
gptkbp:mechanismOfAction
|
inhibit bacterial protein synthesis
|
|
gptkbp:origin
|
produced by Streptomyces species
|
|
gptkbp:pregnancyCategory
|
varies by drug
|
|
gptkbp:relatedTo
|
gptkb:lincosamides
streptogramins
|
|
gptkbp:resistantTo
|
efflux pumps
methylation of 23S rRNA
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
QT prolongation
gastrointestinal upset
liver enzyme elevation
|
|
gptkbp:spectrumOfActivity
|
Gram-positive bacteria
some Gram-negative bacteria
|
|
gptkbp:structure
|
macrocyclic lactone ring
|
|
gptkbp:target
|
bacterial 50S ribosomal subunit
|
|
gptkbp:usedFor
|
treatment of skin infections
treatment of respiratory tract infections
treatment of sexually transmitted infections
|
|
gptkbp:bfsParent
|
gptkb:cytochrome_P450_enzymes
gptkb:23S_rRNA
gptkb:ergotamine
gptkb:Erythrocin
gptkb:J01FA01
|
|
gptkbp:bfsLayer
|
6
|