|
gptkbp:instanceOf
|
gptkb:enzyme
superfamily
|
|
gptkbp:alternativeName
|
gptkb:P450
CYP
cytochrome P-450
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:contains
|
heme as a cofactor
|
|
gptkbp:discoveredBy
|
gptkb:Osamu_Hayaishi
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:EC_number
|
1.14.-.-
|
|
gptkbp:encodedBy
|
CYP genes
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
fungi
plants
archaea
|
|
gptkbp:function
|
catalyzes oxidation of organic substances
|
|
gptkbp:GO_term
|
GO:0004497
|
|
gptkbp:hasWikipediaPage
|
https://en.wikipedia.org/wiki/Cytochrome_P450
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cytochrome P450
|
|
gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:carbamazepine
phenobarbital
|
|
gptkbp:inhibitedBy
|
gptkb:milk
gptkb:macrolide_antibiotics
azole antifungals
|
|
gptkbp:involvedIn
|
synthesis of cholesterol
drug metabolism
synthesis of steroids
synthesis of lipids
|
|
gptkbp:MeSH_ID
|
D003562
|
|
gptkbp:namedFor
|
absorption peak at 450 nm
|
|
gptkbp:OMIM
|
606760
|
|
gptkbp:presentIn
|
gptkb:endoplasmic_reticulum
mitochondria
|
|
gptkbp:proteinFamily
|
CYP
|
|
gptkbp:relatedTo
|
detoxification
electron transport chain
hydroxylation
xenobiotic metabolism
|
|
gptkbp:subclassOf
|
oxidoreductase
monooxygenase
|
|
gptkbp:subfamily
|
gptkb:CYP1
gptkb:CYP11
gptkb:CYP17
gptkb:CYP19
gptkb:CYP2
gptkb:CYP21
gptkb:CYP24
gptkb:CYP27
gptkb:CYP3
gptkb:CYP4
gptkb:CYP46
gptkb:CYP51
gptkb:CYP7
gptkb:CYP8
CYP5
|
|
gptkbp:UniProtID
|
P00183
|
|
gptkbp:bfsParent
|
gptkb:CYP_enzymes
gptkb:Pfam:_PF00067
|
|
gptkbp:bfsLayer
|
7
|