|
gptkbp:instanceOf
|
gptkb:nonsteroidal_anti-inflammatory_drug
|
|
gptkbp:ATCCode
|
M01AE01
|
|
gptkbp:availableOn
|
gptkb:tablet
capsule
suspension
injection
gel
|
|
gptkbp:brand
|
gptkb:Nurofen
gptkb:Motrin
gptkb:Advil
|
|
gptkbp:CASNumber
|
15687-27-1
|
|
gptkbp:chemicalFormula
|
C13H18O2
|
|
gptkbp:contraindication
|
gptkb:kidney_disease
gptkb:peptic_ulcer
asthma
pregnancy (third trimester)
|
|
gptkbp:discoveredBy
|
gptkb:John_Nicholson
gptkb:Stewart_Adams
|
|
gptkbp:discoveredIn
|
1961
|
|
gptkbp:drugClass
|
gptkb:propionic_acid_derivative
|
|
gptkbp:eliminationHalfLife
|
2–4 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:FDAApproved
|
1974
|
|
gptkbp:first_marketed
|
1969
|
|
gptkbp:interactsWith
|
gptkb:warfarin
gptkb:aspirin
gptkb:methotrexate
lithium
|
|
gptkbp:IUPACName
|
(RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid
|
|
gptkbp:legalStatus
|
over-the-counter
prescription (higher doses)
|
|
gptkbp:mechanismOfAction
|
COX inhibitor
|
|
gptkbp:meltingPoint
|
75–78 °C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:origin
|
gptkb:United_Kingdom
|
|
gptkbp:pregnancyCategory
|
C (first and second trimester)
D (third trimester)
|
|
gptkbp:routeOfAdministration
|
oral
topical
intravenous
|
|
gptkbp:sideEffect
|
nausea
dizziness
headache
gastrointestinal upset
|
|
gptkbp:sold_as_racemate
|
yes
|
|
gptkbp:solubility
|
very low
|
|
gptkbp:usedFor
|
pain relief
fever reduction
inflammation reduction
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Motrin
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ibuprofen
|