ibuprofen

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf nonsteroidal anti-inflammatory drug
gptkbp:ATCCode M01AE01
gptkbp:availableOn gptkb:tablet
capsule
suspension
injection
gel
gptkbp:brand gptkb:Nurofen
gptkb:Motrin
gptkb:Advil
gptkbp:CASNumber 15687-27-1
gptkbp:chemicalFormula C13H18O2
gptkbp:contraindication asthma
kidney disease
peptic ulcer
pregnancy (third trimester)
gptkbp:discoveredBy gptkb:John_Nicholson
gptkb:Stewart_Adams
gptkbp:discoveredIn 1961
gptkbp:drugClass propionic acid derivative
gptkbp:eliminationHalfLife 2–4 hours
gptkbp:excretion gptkb:kidney
gptkbp:FDAApproved 1974
gptkbp:first_marketed 1969
https://www.w3.org/2000/01/rdf-schema#label ibuprofen
gptkbp:interactsWith gptkb:warfarin
gptkb:aspirin
gptkb:methotrexate
lithium
gptkbp:IUPACName (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid
gptkbp:legalStatus over-the-counter
prescription (higher doses)
gptkbp:mechanismOfAction COX inhibitor
gptkbp:meltingPoint 75–78 °C
gptkbp:metabolism liver
gptkbp:origin gptkb:United_Kingdom
gptkbp:pregnancyCategory C (first and second trimester)
D (third trimester)
gptkbp:routeOfAdministration oral
topical
intravenous
gptkbp:sideEffect nausea
dizziness
headache
gastrointestinal upset
gptkbp:sold_as_racemate yes
gptkbp:solubility very low
gptkbp:usedFor pain relief
fever reduction
inflammation reduction
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Motrin
gptkbp:bfsLayer 5