|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:RAS
|
|
gptkbp:alternativeName
|
gptkb:RAF_proto-oncogene_serine/threonine-protein_kinase
gptkb:RAF1
|
|
gptkbp:associatedWith
|
gptkb:LEOPARD_syndrome
gptkb:cancer
gptkb:Noonan_syndrome
|
|
gptkbp:discoveredBy
|
gptkb:Hartmut_Beug
|
|
gptkbp:encodedBy
|
gptkb:RAF1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:RAF1
5894
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.1
|
|
gptkbp:function
|
signal transduction
serine/threonine-protein kinase activity
|
|
gptkbp:HGNC_ID
|
9829
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C-RAF
|
|
gptkbp:inhibitedBy
|
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:KRAS
gptkb:SRC
gptkb:GRB2
gptkb:HSP90
gptkb:B-RAF
|
|
gptkbp:locatedOnChromosome
|
3p25
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
gptkb:MAPK/ERK_pathway
|
|
gptkbp:molecularWeight
|
73 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
tumorigenesis
|
|
gptkbp:OMIM
|
164760
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:3OMV
gptkb:4G0N
gptkb:6Q0J
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_002867.1
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P04049
|
|
gptkbp:bfsParent
|
gptkb:A-RAF
gptkb:A-RAF_proto-oncogene,_serine/threonine_kinase
|
|
gptkbp:bfsLayer
|
7
|