|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NS7
gptkb:RAFB1
gptkb:BRAF
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
melanoma
|
|
gptkbp:discoveredBy
|
Marais et al.
|
|
gptkbp:encodedBy
|
gptkb:BRAF_gene
|
|
gptkbp:Entrez_Gene_ID
|
673
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
serine/threonine-protein kinase
|
|
gptkbp:HGNC_ID
|
1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B-RAF
|
|
gptkbp:inhibitedBy
|
gptkb:sorafenib
LGX818
PLX4720
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedIn
|
gptkb:Homo_sapiens
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
|
|
gptkbp:memberOf
|
gptkb:RAF_kinase_family
|
|
gptkbp:mutationAssociatedWith
|
fusion
missense
V600E
in-frame deletion
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:RAS-RAF-MEK-ERK_pathway
|
|
gptkbp:PDB
|
gptkb:1UWH
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
|
|
gptkbp:RefSeq
|
NM_004333
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:structure
|
kinase domain
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:Braf
|
|
gptkbp:bfsLayer
|
6
|