|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:RAF_family
|
|
gptkbp:BRAF
|
frequently mutated in melanoma
|
|
gptkbp:composedOf
|
gptkb:ARAF
gptkb:BRAF
gptkb:CRAF
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:downstreamOf
|
gptkb:RAS
gptkb:MEK
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:foundIn
|
gptkb:metazoans
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
gptkbp:humanGenes
|
gptkb:ARAF
gptkb:BRAF
gptkb:RAF1
|
|
gptkbp:inhibitedBy
|
gptkb:dabrafenib
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locale
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
|
|
gptkbp:namedAfter
|
gptkb:Rapidly_Accelerated_Fibrosarcoma
|
|
gptkbp:orthologIn
|
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:proteinFamily
|
protein kinases
|
|
gptkbp:regulates
|
cell differentiation
cell survival
cell division
|
|
gptkbp:bfsParent
|
gptkb:3p25_(CRAF)
gptkb:ARAF
gptkb:BRAF_gene
gptkb:P10398_(ARAF)
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAF kinase family
|