Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:RAF_family
|
| gptkbp:BRAF |
frequently mutated in melanoma
|
| gptkbp:composedOf |
gptkb:ARAF
gptkb:BRAF gptkb:CRAF |
| gptkbp:discoveredIn |
1980s
|
| gptkbp:downstreamOf |
gptkb:RAS
gptkb:MEK |
| gptkbp:EC_number |
2.7.11.1
|
| gptkbp:foundIn |
gptkb:metazoans
|
| gptkbp:function |
serine/threonine-protein kinase activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
RAF kinase family
|
| gptkbp:humanGenes |
gptkb:ARAF
gptkb:BRAF gptkb:RAF1 |
| gptkbp:inhibitedBy |
gptkb:dabrafenib
gptkb:sorafenib gptkb:vemurafenib |
| gptkbp:involvedIn |
gptkb:MAPK/ERK_signaling_pathway
|
| gptkbp:locale |
gptkb:cell_membrane
gptkb:cytoplasm |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
|
| gptkbp:namedAfter |
gptkb:Rapidly_Accelerated_Fibrosarcoma
|
| gptkbp:orthologIn |
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster |
| gptkbp:proteinFamily |
protein kinases
|
| gptkbp:regulates |
cell differentiation
cell survival cell division |
| gptkbp:bfsParent |
gptkb:BRAF_gene
|
| gptkbp:bfsLayer |
5
|