Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
gptkb:Nucleophosmin
B23 NO38 |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:acute_myeloid_leukemia
myelodysplastic syndrome solid tumors |
| gptkbp:clinicalTrialPhase |
NPM1 mutation analysis for AML diagnosis
|
| gptkbp:discoveredBy |
K. Chan et al.
|
| gptkbp:discoveredIn |
1989
|
| gptkbp:encodes |
nucleophosmin protein
|
| gptkbp:Entrez_Gene_ID |
4869
ENSG00000181163 |
| gptkbp:fullName |
Nucleophosmin 1
|
| gptkbp:function |
ribosome biogenesis
nucleolar organization regulation of ARF tumor suppressor |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
HGNC:7910
|
| https://www.w3.org/2000/01/rdf-schema#label |
NPM1 gene
|
| gptkbp:interactsWith |
gptkb:p53_protein
ribosomal proteins ARF protein HDM2 protein |
| gptkbp:length |
294 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5
5q35.1 |
| gptkbp:mutationAssociatedWith |
gptkb:acute_myeloid_leukemia
frameshift mutation insertion mutation |
| gptkbp:OMIM |
164040
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Npm1
|
| gptkbp:pathway |
cell cycle regulation
p53 signaling pathway ribosome biogenesis pathway |
| gptkbp:proteinFamily |
oligomerization domain
nuclear localization signal acidic stretches nucleic acid binding domain nucleophosmin/nucleoplasmin family |
| gptkbp:subcellularLocation |
nucleolus
nucleoplasm cytoplasm (in mutated form) cytoplasm (mutant) |
| gptkbp:tissue_specificity |
ubiquitous
|
| gptkbp:UniProtID |
P06748
|
| gptkbp:bfsParent |
gptkb:NPM1_mutation
gptkb:NPM1 |
| gptkbp:bfsLayer |
6
|