Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
peptide
senolytic agent |
| gptkbp:administeredBy |
intraperitoneal injection
|
| gptkbp:canBe |
anti-aging therapy
treatment of age-related diseases |
| gptkbp:composition |
D-retro-inverso peptide
|
| gptkbp:developedBy |
gptkb:Peter_de_Keizer
|
| gptkbp:effect |
improves healthspan in mice
induces apoptosis in senescent cells reduces senescent cell burden restores tissue homeostasis |
| https://www.w3.org/2000/01/rdf-schema#label |
peptide FOXO4-DRI
|
| gptkbp:mechanismOfAction |
disrupts FOXO4-p53 binding
|
| gptkbp:publicationYear |
2017
|
| gptkbp:relatedTo |
gptkb:FOXO4_protein
gptkb:p53_protein cellular senescence |
| gptkbp:studiedIn |
mouse models
|
| gptkbp:target |
FOXO4-p53 interaction
|
| gptkbp:bfsParent |
gptkb:Peter_de_Keizer
|
| gptkbp:bfsLayer |
6
|