|
gptkbp:instanceOf
|
signaling molecule
|
|
gptkbp:activatedBy
|
gptkb:insulin
cytokines
growth factors
|
|
gptkbp:component
|
gptkb:PI3K_(phosphoinositide_3-kinase)
gptkb:mTOR_(mechanistic_target_of_rapamycin)
Akt (protein kinase B)
|
|
gptkbp:crossTalksWith
|
gptkb:MAPK_pathway
gptkb:AMPK_pathway
|
|
gptkbp:downstreamOf
|
gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
|
|
gptkbp:firstDescribed
|
1990s
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PI3K-Akt-mTOR pathway
|
|
gptkbp:involves
|
gptkb:Akt
gptkb:PI3K
gptkb:mTOR
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:cytoplasm
|
|
gptkbp:negativelyRegulatedBy
|
gptkb:PTEN
gptkb:TSC1/TSC2_complex
|
|
gptkbp:regulates
|
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
|
|
gptkbp:role
|
glucose uptake
lipid synthesis
protein synthesis
immune response
autophagy
apoptosis inhibition
|
|
gptkbp:studiedIn
|
neuroscience
oncology
metabolic diseases
|
|
gptkbp:target
|
gptkb:rapamycin
PI3K inhibitors
mTOR inhibitors
Akt inhibitors
|
|
gptkbp:bfsParent
|
gptkb:mechanistic_target_of_rapamycin
|
|
gptkbp:bfsLayer
|
7
|