mechanistic target of rapamycin complex 1
GPTKB entity
Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:mTORC1
|
| gptkbp:activatedBy |
growth factors
amino acids |
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases metabolic diseases |
| gptkbp:component |
gptkb:Deptor
gptkb:PRAS40 gptkb:mLST8 gptkb:bird gptkb:mTOR |
| gptkbp:discoveredIn |
2002
|
| gptkbp:function |
regulation of autophagy
regulation of cell growth regulation of protein synthesis |
| gptkbp:gene |
gptkb:DEPTOR
gptkb:MLST8 gptkb:MTOR gptkb:AKT1S1 gptkb:RPTOR |
| https://www.w3.org/2000/01/rdf-schema#label |
mechanistic target of rapamycin complex 1
|
| gptkbp:inhibitedBy |
gptkb:rapamycin
nutrient deprivation |
| gptkbp:location |
gptkb:cytoplasm
lysosomal membrane |
| gptkbp:phosphorylates |
gptkb:4EBP1
gptkb:S6K1 |
| gptkbp:relatedTo |
gptkb:mechanistic_target_of_rapamycin_complex_2
|
| gptkbp:bfsParent |
gptkb:mTORC1
|
| gptkbp:bfsLayer |
6
|