|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:HRas_proto-oncogene,_GTPase
gptkb:c-Ha-ras
gptkb:Harvey_rat_sarcoma_viral_oncogene_homolog
|
|
gptkbp:associatedWith
|
gptkb:oral_squamous_cell_carcinoma
gptkb:cancer
gptkb:Costello_syndrome
bladder cancer
|
|
gptkbp:clinicalTrialPhase
|
HRAS mutation analysis
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodes
|
gptkb:GTPase_HRas
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000174775
3265
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
signal transduction
GTP binding
GTPase activity
|
|
gptkbp:gene
|
gptkb:HRAS
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
5173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human HRAS
|
|
gptkbp:interactsWith
|
gptkb:RASA1
gptkb:GRB2
gptkb:PIK3CA
gptkb:RAF1
gptkb:SOS1
|
|
gptkbp:length
|
6 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
chromosome 11
|
|
gptkbp:mutationAssociatedWith
|
cell proliferation
oncogenic transformation
tumorigenesis
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:orthologInMouse
|
gptkb:Hras1
Hras
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
phosphorylation
|
|
gptkbp:proteinFamily
|
gptkb:Ras_family
|
|
gptkbp:regulates
|
regulated by GTP/GDP binding
|
|
gptkbp:subcellularLocation
|
gptkb:Golgi_apparatus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:Drosophila_Ras85D
|
|
gptkbp:bfsLayer
|
5
|