glycogen synthase kinase 3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:GSK-3
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:cancer gptkb:diabetes_mellitus bipolar disorder
gptkbp:biologicalProcess	protein serine/threonine kinase activity
gptkbp:discoveredBy	gptkb:Dale_E._Krebs
gptkbp:discoveredIn	1980
gptkbp:EC_number	2.7.11.26
gptkbp:encodedBy	gptkb:GSK3A_gene gptkb:GSK3B_gene
gptkbp:Entrez_Gene_ID	2932 2931
gptkbp:function	regulation of apoptosis regulation of cell proliferation regulation of Wnt signaling pathway regulation of insulin signaling regulation of glycogen metabolism phosphorylation of glycogen synthase
gptkbp:hasIsoform	gptkb:GSK-3α gptkb:GSK-3β
https://www.w3.org/2000/01/rdf-schema#label	glycogen synthase kinase 3
gptkbp:inhibitedBy	gptkb:SB-216763 gptkb:Tideglusib gptkb:CHIR99021 lithium AR-A014418 BIO (6-bromoindirubin-3'-oxime)
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:organism	gptkb:human gptkb:mouse
gptkbp:pathway	gptkb:PI3K-Akt_signaling_pathway gptkb:Wnt_signaling_pathway cell cycle regulation insulin signaling pathway
gptkbp:regulates	activated by phosphorylation at tyrosine inhibited by phosphorylation at serine
gptkbp:substrate	gptkb:cyclin_D1 gptkb:glycogen_synthase gptkb:tau_protein gptkb:CREB gptkb:c-Myc gptkb:β-catenin
gptkbp:UniProtID	gptkb:P49840 gptkb:P49841
gptkbp:bfsParent	gptkb:14-3-3_proteins gptkb:14-3-3_protein
gptkbp:bfsLayer	7