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gptkbp:instanceOf
|
enzyme superfamily
|
|
gptkbp:alsoKnownAs
|
CYPs
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gptkbp:cofactor
|
gptkb:cytochrome_P450_reductase
NADPH
|
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gptkbp:contains
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gptkb:heme_cofactor
|
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gptkbp:discoveredBy
|
M. J. Klingenberg
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:EC_number
|
1.14.-.-
|
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gptkbp:foundIn
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gptkb:endoplasmic_reticulum
gptkb:Bacteria
humans
liver
mitochondria
archaea
eukaryotes
|
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gptkbp:function
|
monooxygenase activity
drug metabolism
xenobiotic metabolism
biosynthesis of cholesterol
biosynthesis of lipids
biosynthesis of steroids
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https://www.w3.org/2000/01/rdf-schema#label
|
cytochrome P450 enzymes
|
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gptkbp:inducedBy
|
gptkb:rifampicin
gptkb:phenytoin
gptkb:carbamazepine
|
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gptkbp:inhibitedBy
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gptkb:milk
gptkb:macrolide_antibiotics
azole antifungals
|
|
gptkbp:mutationAssociatedWith
|
adverse drug reactions
altered drug metabolism
pharmacogenetic variability
|
|
gptkbp:namedFor
|
absorption peak at 450 nm
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gptkbp:proteinFamily
|
gptkb:CYP1
gptkb:CYP11
gptkb:CYP17
gptkb:CYP19
gptkb:CYP2
gptkb:CYP21
gptkb:CYP24
gptkb:CYP27
gptkb:CYP3
gptkb:CYP4
gptkb:CYP46
gptkb:CYP51
gptkb:CYP7
CYP5
|
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gptkbp:relatedTo
|
oncology
toxicology
endocrinology
environmental health
pharmacogenomics
|
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gptkbp:substrate
|
gptkb:codeine
gptkb:cyclosporine
gptkb:warfarin
gptkb:omeprazole
gptkb:estradiol
gptkb:diazepam
ethanol
caffeine
statins
acetaminophen
nicotine
testosterone
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gptkbp:bfsParent
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gptkb:CYP2_family
gptkb:CYP4_family
|
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gptkbp:bfsLayer
|
5
|