|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:absorbancePeak
|
450 nm
|
|
gptkbp:alsoKnownAs
|
gptkb:cytochrome_P450_enzymes
|
|
gptkbp:cofactor
|
gptkb:cytochrome_P450_reductase
hemoglobin
NADPH
|
|
gptkbp:contains
|
gptkb:CYP1_family
gptkb:CYP2_family
gptkb:CYP3_family
gptkb:CYP4_family
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Klingenberg
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
CYP genes
|
|
gptkbp:foundIn
|
gptkb:cancer
gptkb:kidney
liver
intestine
|
|
gptkbp:function
|
catalyze oxidation of organic substances
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CYP450 enzymes
|
|
gptkbp:importantIsoforms
|
gptkb:CYP1A2
gptkb:CYP2C9
gptkb:CYP2C19
gptkb:CYP2D6
gptkb:CYP3A4
CYP2E1
|
|
gptkbp:inducedBy
|
gptkb:phenytoin
gptkb:rifampin
gptkb:carbamazepine
|
|
gptkbp:inhibitedBy
|
gptkb:milk
azole antifungals
|
|
gptkbp:mechanismOfAction
|
monooxygenase activity
|
|
gptkbp:mutationAssociatedWith
|
altered drug metabolism
|
|
gptkbp:presentIn
|
gptkb:Bacteria
animals
fungi
plants
|
|
gptkbp:role
|
cholesterol metabolism
detoxification
drug metabolism
hormone synthesis
|
|
gptkbp:significance
|
pharmacogenomics
adverse drug reactions
drug-drug interactions
|
|
gptkbp:structure
|
contains heme iron
|
|
gptkbp:substrate
|
drugs
steroids
fatty acids
xenobiotics
|
|
gptkbp:superfamily
|
gptkb:cytochrome_P450
|
|
gptkbp:bfsParent
|
gptkb:silymarin
|
|
gptkbp:bfsLayer
|
6
|