Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:pharmaceuticals
|
| gptkbp:administered_by |
oral tablet
intravenous injection |
| gptkbp:affects |
bacterial RNA polymerase
|
| gptkbp:approves |
gptkb:1966
|
| gptkbp:atccode |
J04 AB02
|
| gptkbp:brand |
gptkb:Rifadin
gptkb:Rimactane |
| gptkbp:can_be_combined_with |
gptkb:ethambutol
gptkb:isoniazid gptkb:pyrazinamide |
| gptkbp:casnumber |
13292-46-1
|
| gptkbp:category |
Category C
|
| gptkbp:chemical_formula |
C21 H19 N3 O4
|
| gptkbp:contraindication |
hypersensitivity to rifampin
|
| gptkbp:developed_by |
prevention of meningococcal disease
treatment of leprosy Danish pharmaceutical company |
| gptkbp:excretion |
urine
bile |
| https://www.w3.org/2000/01/rdf-schema#label |
Rifampin
|
| gptkbp:interacts_with |
gptkb:warfarin
oral contraceptives |
| gptkbp:is_used_for |
tuberculosis
bacterial infections |
| gptkbp:lifespan |
2 to 5 hours
|
| gptkbp:mechanism_of_action |
inhibits RNA synthesis
|
| gptkbp:side_effect |
gptkb:anemia
dizziness fatigue headache nausea abdominal pain fever jaundice vomiting urticaria gastrointestinal disturbances rash hearing loss insomnia chills peripheral neuropathy sweating severe allergic reactions hemolytic anemia thrombocytopenia acute kidney injury hepatotoxicity anorexia flu-like symptoms thrombotic thrombocytopenic purpura visual disturbances acute liver failure arthralgia myalgia hyperuricemia toxic epidermal necrolysis Stevens-Johnson syndrome orange discoloration of bodily fluids |
| gptkbp:water_resistance |
mutations in rpo B gene
|
| gptkbp:bfsParent |
gptkb:Rifadin
gptkb:Rimactane |
| gptkbp:bfsLayer |
5
|