|
gptkbp:instanceOf
|
gptkb:antibiotic
gptkb:drug
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:J04AB02
|
|
gptkbp:brand
|
Rifadin
Rimactane
|
|
gptkbp:CASNumber
|
gptkb:13292-46-1
|
|
gptkbp:category
|
antineoplastic agent
bactericidal agent
rifamycin antibiotic
|
|
gptkbp:chemicalFormula
|
C43H58N4O12
|
|
gptkbp:contraindication
|
hypersensitivity to rifamycins
|
|
gptkbp:discoveredBy
|
gptkb:Piero_Sensi
Grazia Timbal
|
|
gptkbp:discoveredIn
|
1965
|
|
gptkbp:drugInteraction
|
gptkb:warfarin
protease inhibitors
oral contraceptives
|
|
gptkbp:eliminationHalfLife
|
3-5 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rifampin
|
|
gptkbp:inducedBy
|
gptkb:cytochrome_P450_enzymes
|
|
gptkbp:lactationUse
|
use with caution
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
1971
|
|
gptkbp:mechanismOfAction
|
inhibits DNA-dependent RNA polymerase
|
|
gptkbp:MedlinePlusID
|
a682403
|
|
gptkbp:MeSH_ID
|
D011978
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
822.94 g/mol
|
|
gptkbp:origin
|
derived from rifamycin B
|
|
gptkbp:pregnancyCategory
|
C (US)
use with caution
|
|
gptkbp:PubChem_CID
|
5381226
CHEMBL86
|
|
gptkbp:routeOfAdministration
|
oral
intravenous
|
|
gptkbp:sideEffect
|
rash
hepatotoxicity
gastrointestinal upset
flu-like syndrome
orange discoloration of body fluids
|
|
gptkbp:UNII
|
V6V19DR43D
|
|
gptkbp:usedFor
|
gptkb:Staphylococcus_aureus_infections
tuberculosis
leprosy
meningococcal prophylaxis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:D012627
gptkb:D014244
|
|
gptkbp:bfsLayer
|
7
|