cyclin dependent kinase 4

URI: https://gptkb.org/entity/cyclin_dependent_kinase_4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:cell_division_protein_kinase_4 gptkb:CDK4
gptkbp:associatedWith	gptkb:glioblastoma gptkb:rhabdomyosarcoma melanoma
gptkbp:biologicalProcess	serine/threonine kinase activity
gptkbp:discoveredBy	1992
gptkbp:EC_number	2.7.11.22
gptkbp:encodedBy	gptkb:CDK4_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000135446
gptkbp:formsComplexWith	gptkb:cyclin_D1 gptkb:cyclin_D2 gptkb:cyclin_D3
gptkbp:function	regulation of cell cycle G1 phase progression
gptkbp:gene	gptkb:CDK4
gptkbp:GO_term	GO:0004693
gptkbp:HGNC_ID	1773
https://www.w3.org/2000/01/rdf-schema#label	cyclin dependent kinase 4
gptkbp:inhibitedBy	gptkb:p15INK4b gptkb:p16INK4a gptkb:p18INK4c gptkb:p19INK4d
gptkbp:interactsWith	gptkb:CCND3 gptkb:CCND1 gptkb:CDKN2A gptkb:CDKN2B gptkb:CCND2
gptkbp:locatedOnChromosome	12q14
gptkbp:molecularWeight	34 kDa
gptkbp:OMIM	123829
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Cdk4
gptkbp:PDB	gptkb:2W96
gptkbp:phosphorylates	gptkb:retinoblastoma_protein_(RB1) threonine 172
gptkbp:RefSeq	gptkb:NM_000075
gptkbp:regulates	cell differentiation cell proliferation cellular senescence
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:targetOfDrug	gptkb:palbociclib gptkb:ribociclib gptkb:abemaciclib
gptkbp:UniProtID	P11802
gptkbp:bfsParent	gptkb:HGNC:1784
gptkbp:bfsLayer	7