|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
CYCD2
D2-type cyclin
G1/S-specific cyclin-D2
bcl-1 homolog
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:medulloblastoma
gptkb:Megalencephaly-polymicrogyria-polydactyly-hydrocephalus_syndrome
cell proliferation
|
|
gptkbp:clinicalTrialPhase
|
genetic testing for mutations
|
|
gptkbp:discoveredBy
|
Sherr CJ et al.
|
|
gptkbp:encodes
|
Cyclin D2 protein
|
|
gptkbp:Entrez_Gene_ID
|
894
ENSG00000118971
|
|
gptkbp:expressedIn
|
brain
heart
pancreas
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:fullName
|
gptkb:Cyclin_D2
|
|
gptkbp:function
|
regulation of cell cycle G1/S transition
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1583
|
|
gptkbp:interactsWith
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:length
|
289 amino acids
|
|
gptkbp:locatedOnChromosome
|
12
12p13.32
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:OMIM
|
123833
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
cell cycle
p53 signaling pathway
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:regulates
|
gptkb:RB1
gptkb:E2F_transcription_factors
growth factors
oncogenes
tumor suppressors
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
P30279
|
|
gptkbp:bfsParent
|
gptkb:cyclin_D
gptkb:12p13.31
gptkb:KEGG:_hsa04012
gptkb:12p13.33
gptkb:R-HSA-69563
gptkb:miR-26a
gptkb:chromosome_12p13
gptkb:chromosome_12p13.31
gptkb:12p13
gptkb:MMYC
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CCND2
|