gptkbp:instanceOf
|
gptkb:drug
cyclin-dependent kinase inhibitor
|
gptkbp:administeredBy
|
oral
|
gptkbp:approvalYear
|
2015
|
gptkbp:approvedBy
|
gptkb:United_States
gptkb:FDA
February 2015
|
gptkbp:ATCCode
|
L01EF01
|
gptkbp:bioavailability
|
46%
|
gptkbp:brand
|
gptkb:Ibrance
|
gptkbp:CASNumber
|
gptkb:571190-30-2
|
gptkbp:combines
|
gptkb:fulvestrant
gptkb:letrozole
|
gptkbp:contraindication
|
pregnancy
|
gptkbp:developedBy
|
gptkb:Pfizer
|
gptkbp:eliminationHalfLife
|
29 hours
|
gptkbp:excretion
|
urine
feces
|
gptkbp:hasMolecularFormula
|
C24H29N7O2
|
gptkbp:hasSMILES
|
CC1=CC(=NC(=N1)N2CCN(CC2)C3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5)C(=O)NC6=CC=CC=C6
|
https://www.w3.org/2000/01/rdf-schema#label
|
palbociclib
|
gptkbp:indication
|
HER2-negative breast cancer
hormone receptor-positive breast cancer
|
gptkbp:KEGGID
|
gptkb:D09950
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
inhibits cell cycle progression
|
gptkbp:metabolism
|
liver
|
gptkbp:patent
|
gptkb:Pfizer
|
gptkbp:pregnancyCategory
|
gptkb:D_(Australia)
D (US)
|
gptkbp:prescribes
|
men with advanced breast cancer
postmenopausal women with advanced breast cancer
|
gptkbp:proteinBinding
|
85%
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1899636
4447442
5330286
DB09073
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
nausea
fatigue
neutropenia
leukopenia
|
gptkbp:target
|
gptkb:CDK4
gptkb:CDK6
|
gptkbp:UNII
|
8N3DW7272P
|
gptkbp:usedFor
|
gptkb:cancer
|
gptkbp:bfsParent
|
gptkb:advanced_hormone_receptor-positive,_HER2-negative_breast_cancer
|
gptkbp:bfsLayer
|
6
|