|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CCND3
gptkb:G1/S-specific_cyclin-D3
cyclin-D3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
|
|
gptkbp:binds
|
gptkb:retinoblastoma_protein_(pRb)
|
|
gptkbp:degradedBy
|
gptkb:SCF_ubiquitin_ligase_complex
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:Entrez_Gene_ID
|
896
ENSG00000112576
|
|
gptkbp:expressed_during
|
G1 phase of cell cycle
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:testis
hematopoietic cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
regulation of cell cycle
G1/S transition of mitotic cell cycle
|
|
gptkbp:gene
|
gptkb:CCND3
|
|
gptkbp:HGNC_ID
|
1583
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cyclin D3
|
|
gptkbp:interactsWith
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:involves
|
gptkb:TGF-beta_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
p53 signaling pathway
cell cycle pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:OMIM
|
601460
|
|
gptkbp:orthologInMouse
|
Ccnd3
|
|
gptkbp:PDB
|
gptkb:2W96
|
|
gptkbp:phosphorylates
|
Ser264
Thr283
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:proteinFamily
|
gptkb:cyclin_D_family
|
|
gptkbp:RefSeq
|
NM_001760
|
|
gptkbp:regulates
|
gptkb:E2F_transcription_factors
cell differentiation
cell proliferation
transcriptionally regulated by E2F
regulated by ubiquitin-mediated proteolysis
|
|
gptkbp:structure
|
contains cyclin box domain
|
|
gptkbp:UniProtID
|
P30281
|
|
gptkbp:bfsParent
|
gptkb:CDK4_gene
gptkb:Cell_division_protein_kinase_4
gptkb:Cyclin-dependent_kinase_6
gptkb:cyclin_dependent_kinase_4
|
|
gptkbp:bfsLayer
|
8
|