|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CMM3
gptkb:PSK-J3
p34PSK-J3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
melanoma
|
|
gptkbp:biologicalProcess
|
cell proliferation
cell division
protein serine/threonine kinase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Sherr CJ et al.
|
|
gptkbp:encodes
|
gptkb:CDK4_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000135446
1019
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_4
|
|
gptkbp:function
|
regulation of cell cycle
G1/S cell cycle transition
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
HGNC:1773
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK4 gene
|
|
gptkbp:inhibitedBy
|
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
|
|
gptkbp:interactsWith
|
gptkb:cyclin_D1
gptkb:CDKN2A_(p16INK4a)
gptkb:CDKN2B_(p15INK4b)
gptkb:cyclin_D2
gptkb:cyclin_D3
|
|
gptkbp:length
|
8 exons
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q14
|
|
gptkbp:mutationAssociatedWith
|
missense mutation
amplification
|
|
gptkbp:OMIM
|
123829
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk4
|
|
gptkbp:pathway
|
gptkb:RB_pathway
gptkb:p16INK4a-CDK4_pathway
cell cycle pathway
|
|
gptkbp:proteinFamily
|
gptkb:cyclin-dependent_kinase_family
|
|
gptkbp:regulates
|
RB1 phosphorylation
|
|
gptkbp:UniProtID
|
P11802
|
|
gptkbp:bfsParent
|
gptkb:CDK4
gptkb:familial_atypical_multiple_mole_melanoma_syndrome
|
|
gptkbp:bfsLayer
|
7
|