|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:INK4B
gptkb:p15
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
melanoma
glioma
|
|
gptkbp:biologicalProcess
|
cell cycle arrest
negative regulation of cell proliferation
cyclin-dependent protein serine/threonine kinase inhibitor activity
|
|
gptkbp:discoveredBy
|
Serrano et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:p15INK4b
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000147889
1030
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin_Dependent_Kinase_Inhibitor_2B
|
|
gptkbp:function
|
cell cycle regulation
tumor suppression
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:1788
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN2B
|
|
gptkbp:inhibitedBy
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:length
|
138 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9
9p21.3
|
|
gptkbp:mutationAssociatedWith
|
loss of function leads to increased cancer risk
|
|
gptkbp:neighboringGene
|
gptkb:CDKN2A
gptkb:MTAP
|
|
gptkbp:OMIM
|
600431
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn2b
|
|
gptkbp:pathway
|
gptkb:p16INK4a/ARF_pathway
cell cycle pathway
|
|
gptkbp:proteinFamily
|
ankyrin repeat domain
|
|
gptkbp:regulates
|
gptkb:E2F1
gptkb:TGF-beta
gptkb:SMAD_proteins
G1 phase of cell cycle
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P42772
|
|
gptkbp:bfsParent
|
gptkb:9p21.2
gptkb:CDKN2A
|
|
gptkbp:bfsLayer
|
6
|