cell division protein kinase 4

URI: https://gptkb.org/entity/cell_division_protein_kinase_4
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:CDK4
gptkbp:associatedWith gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
melanoma
gptkbp:EC_number 2.7.11.22
gptkbp:enzymeClassification serine/threonine-protein kinase
gptkbp:function regulation of cell cycle
gptkbp:gene gptkb:CDK4
https://www.w3.org/2000/01/rdf-schema#label cell division protein kinase 4
gptkbp:inhibitedBy gptkb:p15INK4b
gptkb:p16INK4a
gptkb:p18INK4c
gptkb:p19INK4d
gptkbp:interactsWith gptkb:cyclin_D1
gptkb:cyclin_D2
gptkb:cyclin_D3
gptkbp:locatedOnChromosome gptkb:chromosome_12q14
gptkbp:molecularWeight 34 kDa
gptkbp:mutationAssociatedWith linked to familial melanoma
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:mouse_Cdk4
gptkb:rat_Cdk4
gptkbp:phosphorylates gptkb:retinoblastoma_protein_(RB1)
gptkbp:role G1/S cell cycle transition
gptkbp:structure monomer
heterodimer with cyclin D
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID P11802
gptkbp:bfsParent gptkb:Cyclin-dependent_kinase_4
gptkb:cyclin_dependent_kinase_4
gptkbp:bfsLayer 8