|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCL1
gptkb:PRAD1
U21B31
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:mantle_cell_lymphoma
gptkb:cancer
multiple myeloma
|
|
gptkbp:biologicalProcess
|
cell cycle regulation
protein binding
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodes
|
gptkb:Cyclin_D1
|
|
gptkbp:Entrez_Gene_ID
|
595
ENSG00000110092
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin_D1
|
|
gptkbp:function
|
regulation of cell cycle G1/S transition
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:1582
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CCND1
|
|
gptkbp:interactsWith
|
gptkb:RB1
gptkb:p21
gptkb:p27
|
|
gptkbp:involves
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
cell cycle pathway
|
|
gptkbp:length
|
295 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q13
chromosome 11
|
|
gptkbp:mutationAssociatedWith
|
oncogenesis
|
|
gptkbp:OMIM
|
168461
|
|
gptkbp:orthologInMouse
|
gptkb:Ccnd1
|
|
gptkbp:overexpressedIn
|
various cancers
|
|
gptkbp:phosphorylates
|
Thr286
|
|
gptkbp:proteinFamily
|
cyclin family
|
|
gptkbp:RefSeq
|
NM_053056
NP_444284
|
|
gptkbp:regulates
|
gptkb:CDK4
gptkb:CDK6
gptkb:E2F
gptkb:AP-1
|
|
gptkbp:regulationByMicroRNA
|
gptkb:miR-34a
gptkb:miR-16
gptkb:miR-17-5p
|
|
gptkbp:transcriptionRegulationBy
|
gptkb:Wnt_signaling_pathway
estrogen receptor
|
|
gptkbp:UniProtID
|
P24385
|
|
gptkbp:bfsParent
|
gptkb:EGR1
|
|
gptkbp:bfsLayer
|
6
|