retinoblastoma protein (RB1)

URI: https://gptkb.org/entity/retinoblastoma_protein_(RB1)
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:RB_protein
gptkb:pRb
gptkbp:binds gptkb:E2F1
gptkb:HDAC1
LXCXE motif-containing proteins
gptkbp:decommissioned viral oncoproteins (e.g., HPV E7)
gptkbp:dephosphorylatedBy gptkb:protein_phosphatase_1
gptkbp:discoveredBy gptkb:Weinberg_laboratory
gptkbp:encodedBy gptkb:RB1_gene
gptkbp:expressedIn most human tissues
gptkbp:firstDescribed 1986
gptkbp:function tumor suppressor
regulation of cell cycle
https://www.w3.org/2000/01/rdf-schema#label retinoblastoma protein (RB1)
gptkbp:inhibitedBy gptkb:E2F_transcription_factors
gptkbp:locatedOnChromosome 13q14.2
gptkbp:location gptkb:nucleus
gptkbp:molecularWeight ~110 kDa
gptkbp:mutationAssociatedWith gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
gptkbp:OMIM 614041
gptkbp:phosphorylates cyclin-dependent kinases (CDKs)
gptkbp:regulates apoptosis
G1/S cell cycle transition
cellular differentiation
chromatin remodeling
gptkbp:structure pocket domain
gptkbp:UniProtID P06400
gptkbp:bfsParent gptkb:Cell_division_protein_kinase_4
gptkb:cyclin_dependent_kinase_4
gptkbp:bfsLayer 8