retinoblastoma protein (RB1)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:RB_protein gptkb:pRb
gptkbp:binds	gptkb:E2F1 gptkb:HDAC1 LXCXE motif-containing proteins
gptkbp:decommissioned	viral oncoproteins (e.g., HPV E7)
gptkbp:dephosphorylatedBy	gptkb:protein_phosphatase_1
gptkbp:discoveredBy	gptkb:Weinberg_laboratory
gptkbp:encodedBy	gptkb:RB1_gene
gptkbp:expressedIn	most human tissues
gptkbp:firstDescribed	1986
gptkbp:function	gptkb:tumor_suppressor regulation of cell cycle
gptkbp:inhibitedBy	gptkb:E2F_transcription_factors
gptkbp:locatedOnChromosome	13q14.2
gptkbp:location	gptkb:nucleus
gptkbp:molecularWeight	~110 kDa
gptkbp:mutationAssociatedWith	gptkb:small_cell_lung_carcinoma gptkb:retinoblastoma osteosarcoma
gptkbp:OMIM	614041
gptkbp:phosphorylates	cyclin-dependent kinases (CDKs)
gptkbp:regulates	apoptosis G1/S cell cycle transition cellular differentiation chromatin remodeling
gptkbp:structure	pocket domain
gptkbp:UniProtID	P06400
gptkbp:bfsParent	gptkb:Cell_division_protein_kinase_4
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	retinoblastoma protein (RB1)