|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:apoptosome
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:catalyzes
|
cleavage of peptide bonds at aspartic acid residues
|
|
gptkbp:cleavage
|
gptkb:caspase-3
gptkb:caspase-7
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:EC_number
|
3.4.22.62
|
|
gptkbp:encodedBy
|
CASP9 gene
|
|
gptkbp:function
|
initiator caspase in apoptosis
|
|
gptkbp:gene
|
gptkb:CASP9
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
caspase-9
|
|
gptkbp:inhibitedBy
|
gptkb:XIAP
BIRC2
|
|
gptkbp:locatedOnChromosome
|
chromosome 1p36.21
|
|
gptkbp:molecularWeight
|
46 kDa (precursor)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:OMIM
|
602234
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Casp9
|
|
gptkbp:pathway
|
intrinsic apoptotic signaling pathway
caspase activation cascade
|
|
gptkbp:PDB
|
1JXQ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
cleavage
ubiquitination
|
|
gptkbp:structure
|
contains CARD domain
|
|
gptkbp:subcellularLocation
|
mitochondria
cytosol
|
|
gptkbp:UniProtID
|
gptkb:P55211
|
|
gptkbp:bfsParent
|
gptkb:caspases
|
|
gptkbp:bfsLayer
|
7
|