|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:caspase-9
gptkb:caspase-3
gptkb:granzyme_B
|
|
gptkbp:alternativeName
|
CASP-7
CMH-1
ICE-LAP3
apoptotic protease Mch3
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
apoptotic process
inflammatory response
proteolysis
cysteine-type endopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
cytosol
|
|
gptkbp:cleavage_site
|
Asp-Glu-Val-Asp (DEVD)
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:EC_number
|
3.4.22.60
|
|
gptkbp:encodedBy
|
CASP7 gene
|
|
gptkbp:Entrez_Gene_ID
|
840
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:function
|
execution-phase apoptosis
|
|
gptkbp:HGNC_ID
|
HGNC:1507
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caspase-7
|
|
gptkbp:inhibitedBy
|
gptkb:XIAP
survivin
|
|
gptkbp:involves
|
gptkb:disease
development
immune response
cell death
|
|
gptkbp:length
|
303
|
|
gptkbp:locatedOnChromosome
|
chromosome 10q25
|
|
gptkbp:mass_(kDa)
|
34
|
|
gptkbp:OMIM
|
601761
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Casp7
|
|
gptkbp:PDB
|
1F1J
1K86
1SHJ
|
|
gptkbp:RefSeq
|
NM_001227
|
|
gptkbp:relatedTo
|
gptkb:caspase-9
gptkb:caspase-3
caspase-6
|
|
gptkbp:structure
|
heterotetramer
|
|
gptkbp:substrate
|
gptkb:ICAD
gptkb:lamin_A
poly(ADP-ribose) polymerase (PARP)
|
|
gptkbp:UniProtID
|
P55210
|
|
gptkbp:bfsParent
|
gptkb:Caspase
|
|
gptkbp:bfsLayer
|
7
|