|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
cleavage by caspase-8
cleavage by caspase-9
|
|
gptkbp:activation_mechanism
|
proteolytic cleavage
|
|
gptkbp:alternativeName
|
gptkb:Yama
gptkb:CPP32
apopain
|
|
gptkbp:associatedWith
|
gptkb:caspase-7
caspase-6
|
|
gptkbp:cleavage_site
|
Asp-Glu-Val-Asp (DEVD)
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:EC_number
|
3.4.22.56
|
|
gptkbp:family
|
gptkb:caspase_family
|
|
gptkbp:form
|
heterotetramer
|
|
gptkbp:function
|
cysteine-aspartic acid protease
apoptosis execution
|
|
gptkbp:gene
|
gptkb:CASP3
|
|
gptkbp:GO_term
|
GO:0004197 (cysteine-type endopeptidase activity)
GO:0006915 (apoptotic process)
|
|
gptkbp:HGNC_ID
|
HGNC:1504
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
caspase-3
|
|
gptkbp:inhibitedBy
|
gptkb:XIAP
z-DEVD-fmk
|
|
gptkbp:locatedOnChromosome
|
chromosome 4q34
|
|
gptkbp:location
|
gptkb:nucleus
cytosol
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:OMIM
|
600636
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse caspase-3
rat caspase-3
|
|
gptkbp:pathway
|
intrinsic apoptosis pathway
extrinsic apoptosis pathway
|
|
gptkbp:PDB
|
gptkb:1PAU
|
|
gptkbp:product
|
CASP3 gene
|
|
gptkbp:reviewedBy
|
gptkb:Nature
Cell
|
|
gptkbp:role
|
gptkb:Alzheimer's_disease
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:structure
|
large and small subunits
|
|
gptkbp:substrate
|
gptkb:ICAD
lamin proteins
poly(ADP-ribose) polymerase (PARP)
|
|
gptkbp:UniProtID
|
P42574
|
|
gptkbp:bfsParent
|
gptkb:caspase-8
gptkb:caspases
gptkb:granzyme_B
|
|
gptkbp:bfsLayer
|
7
|