Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:activeSiteResidue |
cysteine
|
| gptkbp:alternativeName |
cysteine-aspartic proteases
|
| gptkbp:cleavage |
aspartic acid
|
| gptkbp:discoveredBy |
Nicholas A. Thornberry
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:EC_number |
3.4.22.56
|
| gptkbp:foundIn |
animals
|
| gptkbp:function |
gptkb:protease
apoptosis regulation inflammation regulation |
| gptkbp:GO_term |
GO:0004197
|
| gptkbp:hasMember |
gptkb:caspase-8
gptkb:caspase-1 gptkb:caspase-9 gptkb:caspase-3 gptkb:caspase-7 gptkb:caspase-10 caspase-6 caspase-5 caspase-12 caspase-14 caspase-2 caspase-4 |
| https://www.w3.org/2000/01/rdf-schema#label |
caspases
|
| gptkbp:inhibitedBy |
gptkb:IAP_proteins
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:regulates |
gptkb:Bcl-2_family_proteins
mitochondrial pathway inhibitor of apoptosis proteins death receptor pathway zymogen activation |
| gptkbp:relatedTo |
immune response
cell death necrosis pyroptosis |
| gptkbp:significance |
gptkb:cancer
neurodegenerative diseases autoimmune diseases inflammatory diseases |
| gptkbp:structure |
heterodimer
large and small subunits |
| gptkbp:subclassOf |
cysteine proteases
|
| gptkbp:UniProt_category |
P42574 (caspase-1)
P42574 (caspase-3) P42575 (caspase-2) P55210 (caspase-7) P55211 (caspase-9) Q14790 (caspase-8) |
| gptkbp:bfsParent |
gptkb:granzymes
|
| gptkbp:bfsLayer |
6
|