|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
CED-4 homolog
apaf-1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Xiaodong_Wang
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:domain
|
gptkb:CARD_domain
WD40 repeats
NOD domain
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000121068
|
|
gptkbp:expressedIn
|
ubiquitous in human tissues
|
|
gptkbp:formsComplexWith
|
gptkb:caspase-9
gptkb:cytochrome_c
gptkb:apoptosome
|
|
gptkbp:fullName
|
apoptotic protease activating factor 1
|
|
gptkbp:function
|
apoptosis regulation
activation of caspase-9
|
|
gptkbp:gene
|
APAF1
|
|
gptkbp:GO_term
|
GO:0006915 (apoptotic process)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Apaf-1
|
|
gptkbp:interactsWith
|
gptkb:Bcl-2
gptkb:XIAP
|
|
gptkbp:locatedIn
|
cytosol
|
|
gptkbp:locatedOnChromosome
|
chromosome 12q23
|
|
gptkbp:molecularWeight
|
~140 kDa
|
|
gptkbp:mutationAssociatedWith
|
colorectal cancer
melanoma
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
intrinsic apoptotic signaling pathway
|
|
gptkbp:PDB
|
3J2T
|
|
gptkbp:RefSeq
|
NM_013229
|
|
gptkbp:regulates
|
regulated by cytochrome c release
regulated by dATP/ATP binding
|
|
gptkbp:significance
|
implicated in cancer
implicated in neurodegenerative diseases
|
|
gptkbp:structure
|
heptameric wheel-like complex in apoptosome
|
|
gptkbp:UniProtID
|
O14727
|
|
gptkbp:bfsParent
|
gptkb:Caspase-9
gptkb:CYCS
|
|
gptkbp:bfsLayer
|
7
|