Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
gptkb:receptor_tyrosine_kinases
growth factor receptors |
| gptkbp:discoveredBy |
1980s
|
| gptkbp:downstream_effector |
gptkb:PI3K
gptkb:RAF_kinase gptkb:RalGDS |
| https://www.w3.org/2000/01/rdf-schema#label |
Ras pathway
|
| gptkbp:includes |
gptkb:MAPK_pathway
gptkb:PI3K_pathway |
| gptkbp:inhibitedBy |
farnesyltransferase inhibitors
|
| gptkbp:involves |
gptkb:GAPs_(GTPase-activating_proteins)
gptkb:GEFs_(guanine_nucleotide_exchange_factors) gptkb:Ras_protein GTPase activity GDP-GTP exchange |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
|
| gptkbp:mutations_found_in |
gptkb:HRAS_gene
gptkb:NRAS_gene gptkb:KRAS_gene |
| gptkbp:namedAfter |
gptkb:Rat_sarcoma_virus
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation cell survival |
| gptkbp:studiedBy |
oncology
|
| gptkbp:bfsParent |
gptkb:c-Met
|
| gptkbp:bfsLayer |
6
|