|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:JAKs
|
|
gptkbp:associatedWith
|
psoriasis
rheumatoid arthritis
myeloproliferative neoplasms
|
|
gptkbp:biologicalProcess
|
protein tyrosine kinase activity
|
|
gptkbp:discoveredBy
|
gptkb:Darnell,_James_E._Jr.
|
|
gptkbp:domain
|
kinase domain
SH2 domain
FERM domain
pseudokinase domain
|
|
gptkbp:enzymeClassification
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:firstDescribed
|
1992
|
|
gptkbp:fullName
|
gptkb:Janus_kinases
|
|
gptkbp:function
|
signal transduction
phosphorylation of STAT proteins
|
|
gptkbp:gene
|
gptkb:JAK2
gptkb:JAK1
gptkb:TYK2
gptkb:JAK3
|
|
gptkbp:GO_term
|
gptkb:GO:0004713
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK kinases
|
|
gptkbp:inhibitedBy
|
JAK inhibitors
|
|
gptkbp:interactsWith
|
gptkb:STAT_proteins
cytokine receptors
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:member
|
gptkb:JAK2
gptkb:JAK1
gptkb:TYK2
gptkb:JAK3
|
|
gptkbp:namedAfter
|
Janus (Roman god)
|
|
gptkbp:OMIM
|
600173
147796
147795
176941
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:phosphorylates
|
gptkb:STAT1
gptkb:STAT2
gptkb:STAT6
gptkb:STAT3
gptkb:STAT5
|
|
gptkbp:regulates
|
cell growth
immune response
hematopoiesis
cytokine signaling
|
|
gptkbp:targetOfDrug
|
gptkb:ruxolitinib
gptkb:tofacitinib
gptkb:baricitinib
|
|
gptkbp:bfsParent
|
gptkb:JAK-STAT_pathway_activation
gptkb:SOCS
gptkb:SOCS_proteins
gptkb:STAT_proteins
|
|
gptkbp:bfsLayer
|
7
|