Signal Transducer and Activator of Transcription proteins

URI: https://gptkb.org/entity/Signal_Transducer_and_Activator_of_Transcription_proteins
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:STAT_proteins
gptkbp:activatedBy cytokines
growth factors
tyrosine phosphorylation
gptkbp:associatedWith gptkb:cancer
autoimmune diseases
inflammatory diseases
gptkbp:binds gptkb:gene
gptkbp:discoveredBy gptkb:James_E._Darnell
gptkbp:domain SH2 domain
DNA-binding domain
transactivation domain
coiled-coil domain
gptkbp:firstDescribed 1994
gptkbp:foundIn mammals
vertebrates
gptkbp:function signal transduction
transcription factor
gptkbp:GO_term GO:0007165
GO:0003700
https://www.w3.org/2000/01/rdf-schema#label Signal Transducer and Activator of Transcription proteins
gptkbp:involvedIn apoptosis
differentiation
cell growth
immune response
oncogenesis
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:member gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT5A
gptkb:STAT5B
gptkb:STAT6
gptkb:STAT3
gptkbp:orthologIn gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkbp:regulates gene expression
gptkbp:relatedTo gptkb:JAK-STAT_signaling_pathway
gptkbp:target small molecule inhibitors
therapeutic drugs
gptkbp:UniProtID P42224 (STAT1)
P42226 (STAT3)
P42229 (STAT5A)
P42230 (STAT5B)
Q14765 (STAT6)
gptkbp:bfsParent gptkb:STATs
gptkb:STAT_proteins
gptkbp:bfsLayer 7