retinoblastoma-associated protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:RB_protein
gptkbp:binds	gptkb:E2F_transcription_factors
gptkbp:component	chromatin nucleoplasm
gptkbp:discoveredBy	gptkb:Brenda_Gallie
gptkbp:discoveredIn	1986
gptkbp:encodedBy	gptkb:RB1_gene
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	tumor suppressor DNA binding transcription corepressor activity
gptkbp:GOProcess	cell cycle arrest negative regulation of cell proliferation
https://www.w3.org/2000/01/rdf-schema#label	retinoblastoma-associated protein
gptkbp:inhibitedBy	cell cycle progression apoptosis (in some contexts)
gptkbp:interactsWith	gptkb:T_antigen_(SV40) gptkb:MDM2 gptkb:BRCA1 gptkb:Cyclin_D1 gptkb:HDAC1 gptkb:p53
gptkbp:locatedIn	gptkb:nucleus
gptkbp:locatedOnChromosome	gptkb:chromosome_13q14
gptkbp:molecularWeight	~110 kDa
gptkbp:mutationAssociatedWith	gptkb:small_cell_lung_carcinoma gptkb:retinoblastoma osteosarcoma
gptkbp:OMIM	614041
gptkbp:orthologIn	gptkb:Danio_rerio gptkb:Mus_musculus gptkb:Drosophila_melanogaster
gptkbp:PDB	1AD6
gptkbp:phosphorylates	gptkb:cyclin-dependent_kinases
gptkbp:postTranslationalModification	phosphorylation ubiquitination acetylation
gptkbp:promotion	cellular differentiation
gptkbp:regulates	gptkb:G1/S_transition
gptkbp:requires	embryonic development
gptkbp:structure	C-terminal domain pocket domain N-terminal domain
gptkbp:target	gptkb:HPV_E7_protein gptkb:SV40_large_T_antigen gptkb:adenovirus_E1A_protein oncogenic viruses
gptkbp:UniProtID	P06400
gptkbp:bfsParent	gptkb:RB1
gptkbp:bfsLayer	6