|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:pRb
gptkb:retinoblastoma-associated_protein
RB
|
|
gptkbp:associatedWith
|
gptkb:retinoblastoma
osteosarcoma
|
|
gptkbp:biologicalProcess
|
chromatin organization
cell cycle arrest
negative regulation of cell proliferation
DNA binding
transcription corepressor activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
gptkb:Stephen_H._Friend
gptkb:Thaddeus_Dryja
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
pRb protein
|
|
gptkbp:Entrez_Gene_ID
|
5925
ENSG00000139687
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Retinoblastoma_1
|
|
gptkbp:function
|
tumor suppressor
|
|
gptkbp:HGNC_ID
|
9884
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rb1
|
|
gptkbp:inhibitedBy
|
gptkb:E2F_transcription_factors
|
|
gptkbp:interactsWith
|
gptkb:MDM2
gptkb:BRCA1
gptkb:Cyclin_D1
gptkb:E2F1
gptkb:HDAC1
gptkb:p53
|
|
gptkbp:involvedIn
|
G1/S cell cycle checkpoint
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_13
13q14.2
|
|
gptkbp:lossOfFunctionLeadsTo
|
uncontrolled cell proliferation
|
|
gptkbp:mutationAssociatedWith
|
germline
increased cancer risk
somatic
|
|
gptkbp:OMIM
|
614041
|
|
gptkbp:orthologInMouse
|
gptkb:Rb1
|
|
gptkbp:orthologInZebrafish
|
rb1
|
|
gptkbp:pathway
|
p53 signaling pathway
cell cycle pathway
|
|
gptkbp:phosphorylates
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:product
|
p105-Rb
|
|
gptkbp:regulates
|
cell cycle
|
|
gptkbp:significance
|
hereditary retinoblastoma
sporadic retinoblastoma
increased risk of secondary cancers
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:bfsParent
|
gptkb:RB1
|
|
gptkbp:bfsLayer
|
6
|