vascular endothelial growth factor

URI: https://gptkb.org/entity/vascular_endothelial_growth_factor
GPTKB entity
Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:VEGF
gptkbp:category gptkb:protein
growth factor
signaling molecule
gptkbp:discoveredBy gptkb:Napoleone_Ferrara
gptkbp:Entrez_Gene_ID 7422 (VEGFA)
ENSG00000112715 (VEGFA)
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
gptkb:placenta
heart
retina
gptkbp:firstDescribed 1989
gptkbp:function increases vascular permeability
stimulates angiogenesis
gptkbp:gene gptkb:VEGFA
gptkb:VEGFB
gptkb:PGF
VEGFC
VEGFD
https://www.w3.org/2000/01/rdf-schema#label vascular endothelial growth factor
gptkbp:locatedOnChromosome chromosome 6 (VEGFA)
gptkbp:location extracellular space
gptkbp:molecularWeight ~45 kDa (VEGFA dimer)
gptkbp:OMIM 192240 (VEGFA)
gptkbp:orthologIn gptkb:meat
gptkb:mouse
gptkb:zebrafish
gptkbp:producedBy macrophages
endothelial cells
tumor cells
gptkbp:recipient gptkb:VEGFR1
gptkb:VEGFR2
gptkb:VEGFR3
gptkbp:regulates gptkb:hypoxia
cytokines
oncogenes
HIF-1
gptkbp:role gptkb:cancer
psoriasis
age-related macular degeneration
diabetic retinopathy
rheumatoid arthritis
gptkbp:structure homodimer
gptkbp:target gptkb:bevacizumab
gptkb:aflibercept
gptkb:ranibizumab
gptkb:pegaptanib
gptkbp:UniProtID P15692 (VEGFA)
gptkbp:bfsParent gptkb:VEGF_signaling_pathway
gptkb:Platelet-derived_growth_factor
gptkbp:bfsLayer 6