vascular endothelial growth factor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:VEGF
gptkbp:category	gptkb:growth_factor gptkb:signaling_molecule gptkb:protein
gptkbp:discoveredBy	gptkb:Napoleone_Ferrara
gptkbp:Entrez_Gene_ID	7422 (VEGFA) ENSG00000112715 (VEGFA)
gptkbp:expressedIn	gptkb:cancer gptkb:kidney gptkb:placenta heart retina
gptkbp:firstDescribed	1989
gptkbp:function	increases vascular permeability stimulates angiogenesis
gptkbp:gene	gptkb:VEGFA gptkb:VEGFB gptkb:PGF VEGFC VEGFD
gptkbp:locatedOnChromosome	chromosome 6 (VEGFA)
gptkbp:location	extracellular space
gptkbp:molecularWeight	~45 kDa (VEGFA dimer)
gptkbp:OMIM	192240 (VEGFA)
gptkbp:orthologIn	gptkb:meat gptkb:mouse gptkb:zebrafish
gptkbp:producedBy	macrophages endothelial cells tumor cells
gptkbp:recipient	gptkb:VEGFR1 gptkb:VEGFR2 gptkb:VEGFR3
gptkbp:regulates	gptkb:hypoxia cytokines oncogenes HIF-1
gptkbp:role	gptkb:age-related_macular_degeneration gptkb:cancer psoriasis diabetic retinopathy rheumatoid arthritis
gptkbp:structure	homodimer
gptkbp:target	gptkb:bevacizumab gptkb:aflibercept gptkb:ranibizumab gptkb:pegaptanib
gptkbp:UniProtID	P15692 (VEGFA)
gptkbp:bfsParent	gptkb:VEGF_signaling_pathway gptkb:Vascular_Endothelial_Growth_Factor_Receptor gptkb:Platelet-derived_growth_factor gptkb:Vascular_permeability_factor
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	vascular endothelial growth factor