|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
D6S217E
Miz1
PIASX
PIASx
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
Tan J et al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:domain
|
gptkb:PINIT_domain
gptkb:SAP_domain
gptkb:SIM_domain
S/T-rich region
SP-RING-type zinc finger
|
|
gptkbp:encodes
|
Protein Inhibitor of Activated STAT 2
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000134853
9063
|
|
gptkbp:function
|
transcriptional coregulator
E3 SUMO-protein ligase activity
|
|
gptkbp:HGNC_ID
|
HGNC:17062
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PIAS2
|
|
gptkbp:interactsWith
|
gptkb:SMAD3
gptkb:STAT1
gptkb:CREBBP
gptkb:CBP
gptkb:STAT2
gptkb:STAT4
gptkb:SMAD4
gptkb:p53
gptkb:LEF1
gptkb:androgen_receptor
gptkb:DNMT3A
gptkb:DNMT3B
gptkb:NCOA1
gptkb:NCOA2
gptkb:NCOA3
GFI1
GFI1B
|
|
gptkbp:length
|
621 amino acids (isoform 1)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_18
|
|
gptkbp:molecularWeight
|
~71 kDa
|
|
gptkbp:OMIM
|
603566
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Pias2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
|
|
gptkbp:regulates
|
STAT signaling pathway
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
O75925
|
|
gptkbp:bfsParent
|
gptkb:PIAS_proteins
|
|
gptkbp:bfsLayer
|
8
|