|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
Lymphoid enhancer factor-1
TCF1A
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
various cancers
T-cell development
hair follicle development
lymphoid development
|
|
gptkbp:discoveredBy
|
Uwe Grosschedl
|
|
gptkbp:encodes
|
LEF1 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000138795
51176
|
|
gptkbp:expressedIn
|
lymphoid tissues
hair follicles
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:fullName
|
Lymphoid enhancer-binding factor 1
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
transcription factor
regulation of gene expression
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003700 (DNA-binding transcription factor activity)
GO:0016055 (Wnt signaling pathway)
|
|
gptkbp:HGNC_ID
|
6551
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LEF1
|
|
gptkbp:interactsWith
|
gptkb:beta-catenin
|
|
gptkbp:length
|
8 exons
|
|
gptkbp:locatedOnChromosome
|
4
plus
4q25
|
|
gptkbp:molecularWeight
|
44 kDa
|
|
gptkbp:mutationAssociatedWith
|
leukemia
chronic lymphocytic leukemia
solid tumors
|
|
gptkbp:OMIM
|
153245
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Lef1
|
|
gptkbp:PDB
|
3OUX
|
|
gptkbp:proteinFamily
|
gptkb:TCF/LEF_family
|
|
gptkbp:regulates
|
gptkb:CCND1
gptkb:MYC
gptkb:AXIN2
apoptosis
cell differentiation
cell proliferation
target gene expression in Wnt pathway
|
|
gptkbp:transcription_factor_binding
|
gptkb:gene
|
|
gptkbp:transcriptional_co-activator
|
gptkb:beta-catenin
|
|
gptkbp:transcriptional_co-repressor
|
Groucho/TLE
|
|
gptkbp:UniProtID
|
Q9UJU2
|
|
gptkbp:bfsParent
|
gptkb:TCF7L2
|
|
gptkbp:bfsLayer
|
6
|