|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:ACTR
SRC-3
AIB1
RAC3
TRAM-1
|
|
gptkbp:amplifiedIn
|
prostate cancer cells
breast cancer cells
ovarian cancer cells
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
prostate cancer
|
|
gptkbp:discoveredBy
|
multiple research groups
|
|
gptkbp:domain
|
bHLH-PAS domain
Q-rich domain
LXXLL motif
|
|
gptkbp:encodes
|
Nuclear receptor coactivator 3 protein
|
|
gptkbp:Entrez_Gene_ID
|
8202
|
|
gptkbp:expressedIn
|
gptkb:endometrium
gptkb:prostate
gptkb:testis
breast tissue
|
|
gptkbp:firstDescribed
|
1997
|
|
gptkbp:fullName
|
Nuclear receptor coactivator 3
|
|
gptkbp:function
|
coactivator for nuclear hormone receptors
enhances transcriptional activation
|
|
gptkbp:HGNC_ID
|
7668
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NCOA3
|
|
gptkbp:interactsWith
|
gptkb:CREBBP
gptkb:EP300
gptkb:androgen_receptor
gptkb:NCOA1
gptkb:NCOA2
estrogen receptor alpha
glucocorticoid receptor
|
|
gptkbp:locatedOnChromosome
|
20q12-q13
|
|
gptkbp:molecularWeight
|
~160 kDa
|
|
gptkbp:mutationAssociatedWith
|
oncogenic potential
|
|
gptkbp:OMIM
|
601937
|
|
gptkbp:orthologInMouse
|
Ncoa3
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
cell proliferation
cell survival
gene expression
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q9Y6Q9
|
|
gptkbp:bfsParent
|
gptkb:20q13.2
|
|
gptkbp:bfsLayer
|
7
|